2023-09-21 #### EDDi - EPIDEMIC DISEASE DETECTIVES HAMBURG https://linktr.ee/e.d.d.i. ## Details * Release Date: September 21, 2023 * Game Engine: Unity * Programming Language: C# Sharp * Platforms: Windows, WebGL (Google Chrome) * Genre: Serious Game, Simulation * Modes: Single Player * System requirements: https://docs.unity3d.com/Manual/system-requirements.html Operating System: Windows 7 SP1+, 8, 10, 64-bit versions only GPU: Graphic card supporting DX10 (Shader-Modell 4.0) RAM: Minimum 4GB storage ## Table of Content 1 GAME CREDITS 2 LICENSE AS OF 2023-09-21 3 GAME DEVELOPMENT - SOFTWARE AND TOOLS USED 4 IN-GAME REFERENCES AND FURTHER READING ## Contact EDDi project team juliane.boenecke@bnitm.de maik.helfrich@haw-hamburg.de ## EDDi Game Project EDDi Epidemic Disease Detectives (c) 2023 Boenecke, Juliane, Helfrich, Maik, Massenberg, Eric, Kutsch, Johannes, Meiburg, Marcus, Heinemeyer, Moritz, Schmidt, Peter, Koenen-Rindfrey, Annabell, Nolte, Kristopher, Hebecker, Ralf, & Reintjes, Ralf / Hamburg Open Online University (HOOU), licensed under MIT Permission is hereby granted, free of charge, to any person obtaining a copy of this software and associated documentation files (the "Software"), to deal in the Software without restriction, including without limitation the rights to use, copy, modify, merge, publish, distribute, sublicense, and/or sell copies of the Software, and to permit persons to whom the Software is furnished to do so, subject to the following conditions: The above copyright notice and this permission notice shall be included in all copies or substantial portions of the Software. THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE. ------------------------------------------------------------------------------------------ ### 1 GAME CREDITS Eric Massenberg: Game Design, Project Management, Vision Johannes Kutsch: Game Design, Code Peter Schmidt: Game Design, Code (EDDi Demo Development) Marcus Meiburg: Game Design Annabell Koenen-Rindfrey: 2D Art (EDDi Demo Development) Moritz Heinemeyer: 2D Art Maik Helfrich: Game Concept and Design, Vision Juliane Boenecke: Narrative Design, Writing, Research, Project Management ..................................................... ## Special Thanks To ............. Hamburg University of Applied Sciences (www.haw-hamburg.de/) * Hamburg Open Online University (HOOU) Julia Bieck: Concept Open Educational Ressource * Games Lab, Faculty of Design, Media and Information Maik Helfrich: Concept Open Educational Ressource, Game Design Professor Ralf Hebecker: Project Supervision * Department of Health Sciences, Faculty Life Sciences Professor Dr Ralf Reintjes: Concept Open Educational Ressource, Original Case Study Development Ranjeet Dhonkal: Original Case Study Development ............. Bernhard Nocht Institute for Tropical Medicine (www.bnitm.de) * Department of Infectious Disease Epidemiology Dr Dewi Ismajani Puradiredja: Original Case Study Development PD Dr Norbert G Schwarz (former employee): Original Case Study Development ..................................................... ### Funded By * Hamburg Open Online University (HOOU) www.haw-hamburg.de/hochschule/qualitaet-in-der-lehre/hamburg-open-online-university/ ------------------------------------------------------------------------------------------ ### 2 LICENSE AS OF 2023-09-21 The HOOU Project "EDDi - Epidemic Disease Detectives Hamburg" is releasing the Serious Game "EDDi", an educational simulation scenario, with its code licensed under the MIT License and its game assets, such as text, graphics and audio, licensed under CC BY 4.0, unless otherwise noted or if third party content was used. ..................................................... ## Narrative Design Narrative Design (EDDi Case Study, EDDi Investigation Notebook) created by Juliane Boenecke, Ralf Reintjes, Ranjeet Dhonkal, Norbert G Schwarz and Dewi Ismajani Puradiredja, CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/), files available as Downloadables via https://www.hoou.de/ ..................................................... # Game Assets * Game Scripts “EDDi Evidences” (.xlsx/.csv) by Juliane Boenecke and Peter Schmidt licensed under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/, files available as Downloadables via https://www.hoou.de/ “EDDi Communication Pathways” (.xlsx/.csv) by Juliane Boenecke and Johannes Kutsch licensed under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/, files available as Downloadables via https://www.hoou.de/ Additional Game Script (e.g. email attachments, texbook pages, ...) created by Juliane Boenecke and Eric Massenberg, CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/), via https://www.hoou.de/ ............. * Artwork The EDDi artwork by Annabell Koenen-Rindfrey is provided as Downloadables via https://www.hoou.de/, licensed under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/. The EDDi Artwork was developed using Affinity Designer 1.9.9 (iPad version). Additional epidemiological graphs by Juliane Boenecke are provided as Downloadables via https://www.hoou.de/, licensed under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/. Graphs were developed using software R Studio (Version 1.0.136), packages rgdal, sp, ggplot2, ggsave, readr and base. ............. * Code EDDi was developed with the Unity Framework (https://unity.com/). All scripts written by the EDDi team and which are not part of Unity or .NET, are provided with the MIT License. The code libraries referenced in these scripts are licensed under the terms of their own respective licenses and these code libraries are not part of the assets provided here. Unity PlugIns and Assets: * “ScriptableVariables” (no link available) Copyright (c) 2021 Johannes Kutsch, licensed under MIT (see below) * “Relay” (https://github.com/SixWays/Relay) Copyright (c) 2017 Luke Thompson / Sigtrap Games, licensed under MIT (see below) * "Hierarchy 2" (https://github.com/truongnguyentungduy/hierarchy-2) Copyright (c) 2020 Trương Nguyễn Tùng Duy, licensed under MIT (see below) MIT license statement: Permission is hereby granted, free of charge, to any person obtaining a copy of this software and associated documentation files (the "Software"), to deal in the Software without restriction, including without limitation the rights to use, copy, modify, merge, publish, distribute, sublicense, and/or sell copies of the Software, and to permit persons to whom the Software is furnished to do so, subject to the following conditions: The above copyright notice and this permission notice shall be included in all copies or substantial portions of the Software. THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE. * "DOTween (HOTween v2)" (https://assetstore.unity.com/packages/tools/animation/dotween-hotween-v2-27676) Copyright (c) 2020 Daniele Giardini (Demigiant) You are permitted to use the Standard Version and create and use Modified Versions for any purpose without restriction, provided that you do not Distribute the Modified Version. You may Distribute verbatim copies of the Source form of the Standard Version of this Package in any medium without restriction, either gratis or for a Distributor Fee, provided that you duplicate all of the original copyright notices and associated disclaimers and also include the original readme.txt file. At your discretion, such verbatim copies may or may not include a Compiled form of the Package. Any use, modification, and distribution of the Standard or Modified Versions is governed by this Artistic License. By using, modifying or distributing the Package, you accept this license. Do not use, modify, or distribute the Package, if you do not accept this license. This license does not grant you the right to use any trademark, service mark, tradename, or logo of the Copyright Holder. THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE. ..................................................... ## Third Party Content / Audio and Sounds * Background Music (Loop) “Sneaky Adventure” by Kevin MacLeod (incompetech.com) Licensed under CC BY 3.0 http://creativecommons.org/licenses/by/3.0/ [modification: song length cut short, loop] “Sneaky Snooper” by Audionautix (audionautix.com) Licensed under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/ [modification: song length cut short, decelerated loop] ............. * Coffee Sounds EDDi Coffee Sip / Email Sent: “Coffee Sip” compilation by Henning Sommer (all rights reserved) EDDi Coffee Refill / Start New Day: “Coffee Refill” compilation by Henning Sommer (all rights reserved) ............. * Mailing System EDDi Cookie Crunch – Call it a Day: “Chewing Crunch Cornflakes Knuspern Schnurpsen Eating Essen Munch” by Borgory (https://freesound.org/people/Borgory/sounds/548367/) licensed under CC0 https://creativecommons.org/publicdomain/zero/1.0/ (modification: length cut short, rearrangement) EDDi Incoming Email: “Messenger Notification Sound Imitation” by Daphne_in_Wonderland (https://freesound.org/people/Daphne_in_Wonderland/sounds/400697/) licensed under CC BY 3.0 https://creativecommons.org/licenses/by/3.0/ (no modifications) EDDi Email Sending Error: “8-bit Deny/Error sound” by philRacoIndie (https://freesound.org/people/philRacoIndie/sounds/551543/) licensed under CC0 https://creativecommons.org/publicdomain/zero/1.0/ (no modifications) ............. * Investigation Notebook and Evidences EDDi Detect Single Evidence: “320655__rhodesmas__level-up-01” by shinephoenixstormcrow (https://freesound.org/people/shinephoenixstormcrow/sounds/337049/) licensed under CC BY 3.0 https://creativecommons.org/licenses/by/3.0/ (no modifications) EDDi All Evidence Data Found: “Success 04” by rhodesmas (https://freesound.org/people/rhodesmas/sounds/322929/) licensed under CC BY 3.0 https://creativecommons.org/licenses/by/3.0/ (no modifications) EDDi Magnifying Glass Discovery: “Searching 01” by rhodesmas (https://freesound.org/people/rhodesmas/sounds/342754/) licensed under CC BY 3.0 https://creativecommons.org/licenses/by/3.0/ (modifications: accelerated) ------------------------------------------------------------------------------------------ ### 4 GAME DEVELOPMENT - SOFTWARE AND TOOLS USED * Collaborative Tools Discord (Version 0.0.263) (free version) https://discord.com/ Miro: Online collaborative White Board (free version) https://miro.com/ HacknPlan: Project Management for Game Development (free version) https://hacknplan.com/ Docs.Google Spreadsheets and Document (free version) https://www.google.de/intl/en/docs/about/ ............. * Game Development Rider Bugfix (Version 2021.1.3) (fee-based version) https://www.jetbrains.com/rider/ Unity (Version 2020.1.0f1) (free version) https://unity.com GitHub: Internet hosting for software development and version control (free version) https://github.com/ Sourcetree (Version 3.4.3): Free Git client for Windows and Mac (free version) https://www.sourcetreeapp.com/ ............. * Art Adobe Illustrator Creative Suite (CS) 6 (fee-based version) https://helpx.adobe.com/at/illustrator/release-note/illustrator-cs6-release-notes.html Affinity Designer (Version 1.9.9 for IPad) (fee-based version) https://affinity.serif.com/de/designer/ R Studio (Version 1.0.136), packages rgdal, sp, ggplot2, ggsave, readr and base ------------------------------------------------------------------------------------------ ### IN-GAME REFERENCES AND FURTHER READING The EDDi scenario is based on a true event and draws on various reference materials to tell a story that is as close to reality as possible. ............. Appel B, 2012. EHEC outbreak 2011: Investigation of the outbreak along the food chain; Bundesinstitut für Risikobewertung, Eds.; BfR: Berlin, 2012. ISBN 978-3-938163-90-0. Askar M, Faber MS, Frank C, Bernard H, Gilsdorf A, Fruth A, Prager R, Höhle M, Suess T, Wadl M, et al., 2011. Update on the ongoing outbreak of haemolytic uraemic syndrome due to Shiga toxin-producing Escherichia coli (STEC) serotype O104, Germany, May 2011. Eurosurveillance 2011, 16. DOI: 10.2807/ese.16.22.19883-en Buchholz U, Bernard H, Werber D, Böhmer MM, Remschmid, C, Wilking H, Deleré Y, an der Heiden M, Adlhoch C, Dreesman J, et al., 2011. German Outbreak of Escherichia coli O104:H4 Associated with Sprouts. N. Engl. J. Med. 2011, 365, 1763–1770. DOI: 10.1056/NEJMoa1106482 [Case data reported in this study was used to inform the teaching case study, Figure 2 of this study was used to inform the teaching case study] Burger R, 2012. EHEC O104:H4 IN GERMANY 2011: A large outbreak of bloody diarrhea and haemolytic uraemic syndrome by shiga toxin-producing E.Coli via contaminated food. In: Institute of Medicine (US). Improving Food Safety Through a One Health Approach: Workshop Summary. Washington (DC): National Academies Press (US); 2012. A1. Available from: https://www.ncbi.nlm.nih.gov/books/NBK114499/ (Last access: 2020/11/02) Commission of the European Communities. Lessons learned from the 2011 outbreak of Shiga toxin-producing Escherichia coli (STEC) O104:H4 in sprouted seeds; 2011. SANCO/13004/2011. Online: https://ec.europa.eu/food/system/files/2016-10/biosafety-crisis-cswd_lessons_learned_en.pdf (Last access: 2020/11/02) European Centre for Disease Prevention and Control (ECDC), 2011. EU case definition: HUS caused by epidemic strain Shiga toxin 2-producing Escherichia Coli Available online: https://www.ecdc.europa.eu/en/all-topics-zescherichia-coli-ecolithreats-and-outbreaksoutbreak-stec-0104h4-2011/eu-case-definition (Last access: 2019/11/02) [Original case definitions were used to inform the teaching case study] Exner M, Hartemann P, n.d.. EHEC- Outbreak Management –Learning for the Future – or - „never waste a good crisis“ n.d. (Slideshow). Online: https://www.rudolf-schuelke-foundation.com/media-rudolf-schuelke-stiftung/img/Exner_Introduction_Teil-4.pdf (Last access: 2020/11/02) Fatima R, Aziz M, 2019. Enterohemorrhagic Escherichia Coli (EHEC). In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Online: https://www.ncbi.nlm.nih.gov/books/NBK519509/ (Last access: 2020/11/02) Frank C, Werber D, Cramer JP, Askar M, Faber M, an der Heiden M, Bernard H, Fruth A, Prager R, Spode A, et al, 2011. Epidemic Profile of Shiga-Toxin–Producing Escherichia coli O104:H4 Outbreak in Germany. N. Engl. J. Med., 365, 1771–1780. DOI: 10.1056/NEJMoa1106483 [Case data reported in the studies was used to inform the teaching case study] Harendza S, 2011. “HUS diary” of a German nephrologist during the current EHEC outbreak in Europe. Kidney Int. 2011, 80, 687–689. DOI: 10.1038/ki.2011.238 Hawker J, Begg N, Reintjes R, Ekdahl K, Edeghere O, van Steenbergen JE, 2019. Communicable disease control and health protection handbook; 4th edition.; Wiley-Blackwell: Hoboken, N.J, 2019; ISBN 978-1-119-32805-6 Köckerling E, Karrasch L, Schweitzer A, Razum O, Krause G, 2017. Public Health Research Resulting from One of the World’s Largest Outbreaks Caused by Entero-Hemorrhagic Escherichia coli in Germany 2011: A Review. Front. Public Health 2017, 5, 332. DOI: 10.3389/fpubh.2017.00332 Manitz J, Kneib T, Schlather M, Helbing D, Brockmann D, 2014. Origin Detection During Food-borne Disease Outbreaks – A Case Study of the 2011 EHEC/HUS Outbreak in Germany. PLOS Curr. Outbreaks 2014. DOI: 10.1371/currents.outbreaks.f3fdeb08c5b9de7c09ed9cbcef5f01f2 Robert Koch-Institut (RKI), 2011. Final presentation and evaluation of epidemiological findings in the EHEC O104:H4 Outbreak Germany 2011. 2011, 45. Online: https://www.rki.de/EN/Content/infections/epidemiology/outbreaks/EHEC_O104/EHEC_final_report.pdf?__blob=publicationFile (Last Access: 2019/11/02) [Case data reported in the studies was used to inform the teaching case study] Robert-Koch-Institut (RKI), 2019. Falldefinitionen des Robert Koch-Instituts zur Übermittlung von Erkrankungs- oder Todesfällen und Nachweisen von Krankheitserregern; 2019. Online: https://www.rki.de/DE/Content/Infekt/IfSG/Falldefinition/Downloads/Falldefinitionen_des_RKI_2019.pdf?__blob=publicationFile (Last access: 2020/11/02) Rosner B, Bernard H, Werber D, Faber M, Stark K, Krause G, 2011. Epidemiologie des EHEC O104:H4/HUS-Ausbruchs in Deutschland, Mai bis Juli 2011. J. Für Verbraucherschutz Leb. 2011, 6, 473–481. DOI: 10.1007/s00003-011-0740-1 Salmi IA, Shuaili KA, Metry A, Ismaili FA, Hola A, Hannawi S, 2018. The Epidemiology of Hemolytic Uraemic Syndrome: Clinical Presentation, Laboratory Findings, Management and Outcomes, 2018. Online: https://symbiosisonlinepublishing.com/hematology/hematology19.php (Last access: 2020/11/02) Stark K, 2012. Epidemiologie des EHEC O104:H4 Ausbruchs Sommer 2011, Deutschland 2012 (Slideshow). Online: https://mobil.bfr.bund.de/cm/343/epidemiologie-des-ehec-o104-h4-ausbruchs.pdf (Last access: 2020/11/02) Tahden M, Manitz J, Baumgardt K, Fell G, Kneib T, Hegasy G, 2016. Epidemiological and Ecological Characterization of the EHEC O104:H4 Outbreak in Hamburg, Germany, 2011. PLOS ONE, 11, e0164508. DOI: 10.1371/journal.pone.0164508 [Case data reported in the studies was used to inform the teaching case study] Ullrich S, Bremer P, Neumann-Grutzeck C, Otto H, Rüther C, von Seydewitz CU, Meyer GP, Ahmadi-Simab K, Röther J, Hogan B, et al., 2013. Symptoms and Clinical Course of EHEC O104 Infection in Hospitalized Patients: A Prospective Single Center Study. PLoS ONE, 8, e55278. DOI: 10.1371/journal.pone.0055278 [Case numbers and terminologies have been used and modified for teaching purposes] World Health Organization (WHO), 2011. Public Health Review of the enterohaemorrhagic Escherichia Coli Outbreak in Germany; 2011; p. 9. Online: https://www.euro.who.int/__data/assets/pdf_file/0009/144981/EHEC_outbreak_10_June_2011.pdf (Last access: 2020/11/02) [Case data reported in the studies was used to inform the teaching case study] * Note: Figures and graphs used in the teaching case study do not represent real outbreak numbers. They instead are based on the real-world outbreak dynamics of the 2011 EHEC/HUS outbreak in Hamburg, Germany, described in the listed references. ..................................................... ## In-Game Textbook * Haemolytic Uraemic Syndrome (HUS) Ullrich S, Bremer P, Neumann-Grutzeck C, Otto H, Rüther C, von Seydewitz CU, Meyer GP, Ahmadi-Simab K, Röther J, Hogan B, et al., 2013. Symptoms and Clinical Course of EHEC O104 Infection in Hospitalized Patients: A Prospective Single Center Study. PLoS ONE, 8, e55278. DOI: 10.1371/journal.pone.0055278 Hawker J, Begg N, Reintjes R, Ekdahl K, Edeghere O, van Steenbergen JE, 2019. Communicable disease control and health protection handbook; 4th edition.; Wiley-Blackwell: Hoboken, N.J, 2019; ISBN 978-1-119-32805-6 Frank C, Werber D, Cramer JP, Askar M, Faber M, an der Heiden M, Bernard H, Fruth A, Prager R, Spode A, et al, 2011. Epidemic Profile of Shiga-Toxin–Producing Escherichia coli O104:H4 Outbreak in Germany. N. Engl. J. Med., 365, 1771–1780. DOI: 10.1056/NEJMoa1106483 Kavanagh D, Raman S, Sheerin N, 2014. Management of haemolytic uraemic syndrome. F1000Prime Rep. 2014, 6. DOI: 10.12703/P6-119 Tahden M, Manitz J, Baumgardt K, Fell G, Kneib T, Hegasy G, 2016. Epidemiological and Ecological Characterization of the EHEC O104:H4 Outbreak in Hamburg, Germany, 2011. PLOS ONE, 11, e0164508. DOI: 10.1371/journal.pone.0164508 ............. * Ebola Virus Disease Wikipedia, 2021. Ebola. Online: https://en.wikipedia.org/wiki/Ebola (Last access: 2021/06/21), CC BY-SA 3.0 https://creativecommons.org/licenses/by-sa/3.0/ Robert Koch-Institut, 2020. Ebolafieber: Häufig gestellte Fragen. Online: https://www.rki.de/DE/Content/Infekt/EpidBull/Merkblaetter/Ratgeber_Typhus_Paratyphus.html;jsessionid=812A299D35FC0FC6807463FDE469284B.internet091#doc2374542bodyText17 (Last access: 2021/06/21) ............. * EHEC Hawker J, Begg N, Reintjes R, Ekdahl K, Edeghere O, van Steenbergen JE, 2019. Communicable disease control and health protection handbook; 4th edition.; Wiley-Blackwell: Hoboken, N.J, 2019; ISBN 978-1-119-32805-6. Frank C, Werber D, Cramer JP, Askar M, Faber M, an der Heiden M, Bernard H, Fruth A, Prager R, Spode A, et al, 2011. Epidemic Profile of Shiga-Toxin–Producing Escherichia coli O104:H4 Outbreak in Germany. N. Engl. J. Med., 365, 1771–1780. DOI: 10.1056/NEJMoa1106483 Kavanagh D, Raman S, Sheerin N, 2014. Management of haemolytic uraemic syndrome. F1000Prime Rep. 2014, 6. DOI: 10.12703/P6-119 Tahden M, Manitz J, Baumgardt K, Fell G, Kneib T, Hegasy G, 2016. Epidemiological and Ecological Characterization of the EHEC O104:H4 Outbreak in Hamburg, Germany, 2011. PLOS ONE, 11, e0164508. DOI: 10.1371/journal.pone.0164508 Burger R, 2012. EHEC O104:H4 IN GERMANY 2011: A large outbreak of bloody diarrhea and haemolytic uraemic syndrome by shiga toxin-producing E.Coli via contaminated food. In: Institute of Medicine (US). Improving Food Safety Through a One Health Approach: Workshop Summary. Washington (DC): National Academies Press (US); 2012. A1. Available from: https://www.ncbi.nlm.nih.gov/books/NBK114499/ (Last access: 2020/11/02) ............. * Typhoid Wikipedia, 2021. Typhoid fever. Online: https://en.wikipedia.org/wiki/Typhoid_fever (Last access: 2021/06/21), CC BY-SA 3.0 https://creativecommons.org/licenses/by-sa/3.0/ Robert Koch-Institut, 2008. Typhus abdominalis, Paratyphus: Gesetzliche Grundlage. Online: https://www.rki.de/DE/Content/Infekt/EpidBull/Merkblaetter/Ratgeber_Typhus_Paratyphus.html;jsessionid=812A299D35FC0FC6807463FDE469284B.internet091#doc2374542bodyText17 (Last access: 2021/06/21) ............. * Epidemiological Cheat Sheet Coolboy101pk, 2011. Descriptive and Analytical Epidemiology. Online: https://www.slideshare.net/coolboy101pk/descriptive-and-analytical-epidemiology licensed under CC-BY-SA 4.0 (https://creativecommons.org/licenses/by-sa/4.0/) (Last access: 2021/03/12) Deputy Director for Public Health Science and Surveillance, Center for Surveillance, Epidemiology, and Laboratory Services, Division of Scientific Education and Professional Development, 2012. Principles of Epidemiology in Public Health Practice, Third Edition: An Introduction to Applied Epidemiology and Biostatistics. Lesson 1: Introduction to Epidemiology (Section 5: The Epidemiological Approach). Online: https://www.cdc.gov/csels/dsepd/ss1978/lesson1/section5.html (Last access: 2021/03/12) Rasmussen SA, Goodman RA, Centers for Disease Control and Prevention (U.S.), Eds. 2019. The CDC field epidemiology manual; Fourth edition.; Oxford University Press: Oxford ; New York, 2019; ISBN 978-0-19-093369-2. p.110ff Hawker J, Begg N, Reintjes R, Ekdahl K, Edeghere O, van Steenbergen JE, 2019. Communicable disease control and health protection handbook; 4th edition.; Wiley-Blackwell: Hoboken, N.J, 2019; ISBN 978-1-119-32805-6. ............. * German Health Reporting System (Textbook figure, last page) BVH - Bundesverband Hygiene-Inspektor). Der Hygieneinspektor 02/14 (Fig.1). Online: https://edoc.rki.de/bitstream/handle/176904/2007/20teFClzrKjE.pdf?sequence=1&isAllowed=y (Last Access: 2020/11/11) Krause G, Altmann D, Faensen D, Porten K, Benzler J, Pfoch T, Ammon A, Kramer MH, Claus H, 2007. SurvNet Electronic Surveillance System for Infectious Disease Outbreaks, Germany. Emerg Infect Dis 2007, 13(10), 1548-1555. DOI: 10.3201/eid1310.070253 ### THANK YOU!